Tokai University - Department of Innovative Medical Science, University of Tokyo - Laboratory of Microenvironmental Metabolic Health Sciences, Tokai University, School of Medicine, Department of Pathology, Tokushima University - Division of Bioscience and Bioindustry, Massachusetts General Hospital and Harvard Medical School - Center for Cancer Immunology and Cutaneous Biology Research Center, Shiga University of Medical Science Hospital - Department of Pharmacy, Tohoku University - Department of Pharmaceutical Sciences, Tohoku University - Department of Pharmaceutical Sciences, Tokai University - Department of Hematology and Oncology, Tokai University - Department of Pathology, University of Tokyo - Laboratory of Microenvironmental Metabolic Health Sciences and Tokai University - Department of Innovative Medical Science