Brigham and Women’s Hospital - Division of Genetics, Brigham and Women’s Hospital - Division of Genetics, Massachusetts Institute of Technology and Harvard University - Proteomics Platform, Massachusetts Institute of Technology and Harvard University - Proteomics Platform, Massachusetts Institute of Technology and Harvard University - Proteomics Platform, Brigham and Women’s Hospital - Division of Genetics, Brigham and Women’s Hospital - Division of Genetics, The University of Western Australia - Harry Perkins Institute of Medical Research, Harvard Medical School - Boston Children’s Hospital, Department of Genetics, Harvard University - Department of Anesthesiology, The University of Western Australia - Harry Perkins Institute of Medical Research, Brigham and Women’s Hospital - Division of Genetics, Massachusetts Institute of Technology and Harvard University - Proteomics Platform and Brigham and Women’s Hospital - Division of Genetics