University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Liverpool - Institute of Infection, Veterinary and Ecological Sciences, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, University of Oxford - Sir William Dunn School of Pathology, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Oxford - Peter Medawar Building for Pathogen Research, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Oxford University Hospitals NHS Foundation TrustUniversity of Oxford - Nuffield Department of Clinical Neurosciences, Public Health England Colindale, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool - Institute of Infection, Veterinary and Ecological Sciences, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University - Translational and Clinical Research Institute, University of Oxford - Peter Medawar Building for Pathogen Research, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Sheffield Teaching Hospitals NHS Foundation Trust, Oxford University Hospitals NHS Foundation Trust, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Department of Paediatrics, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Oxford Vaccine Group, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, Public Health England Colindale, University of Birmingham - Institute of Cancer and Genomic Sciences, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - NIHR Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance, Public Health England Colindale, University of Oxford - Sir William Dunn School of Pathology, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Oxford - Peter Medawar Building for Pathogen Research, Mahidol University - Mahidol-Oxford Tropical Medicine Research Unit, University of Birmingham - Institute of Cancer and Genomic Sciences, Newcastle upon Tyne Hospitals NHS Foundation Trust - Department of Infection and Tropical Medicine, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Wellcome Centre for Human Genetics, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease and Independent