Government of the People's Republic of China - Fifth Medical Center, Chinese Academy of Medical Sciences - Key Laboratory of Big Data for Spinal Deformities, Chinese Academy of Medical Sciences - Key Laboratory of Big Data for Spinal Deformities, Government of the People's Republic of China - Fifth Medical Center, Chinese Academy of Medical Sciences - Key Laboratory of Big Data for Spinal Deformities, Government of the People's Republic of China - Fifth Medical Center, Shandong University - Department of Orthopedic Surgery, Government of the People's Republic of China - Fifth Medical Center, Chinese Academy of Medical Sciences - Key Laboratory of Big Data for Spinal Deformities, Government of the People's Republic of China - Fifth Medical Center, Peking University - Institute of Systems Biomedicine, Government of the People's Republic of China - Fifth Medical Center, Government of the People's Republic of China - Fifth Medical Center, Government of the People's Republic of China - Fifth Medical Center, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - Beijing Key Laboratory for Genetic Research of Bone and Joint Disease, Lanzhou University - CHESS Center, Government of the People's Republic of China - Department of Liver Diseases and Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - State Key Laboratory of Complex Severe and Rare Diseases