Sun Yat-sen University (SYSU) - Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, National University of Singapore (NUS) - Department of Biological Sciences, The Chinese University of Hong Kong - Department of Clinical Pathology, National University of Singapore (NUS) - Department of Biological Sciences, Sun Yat-sen University (SYSU) - Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Princeton University - Department of Molecular Biology, The Chinese University of Hong Kong (CUHK) - Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong (CUHK) - Li Ka Shing Institute of Health Sciences, Peking University - Center for Quantitative Biology, Peking University - Center for Quantitative Biology, Columbia University - College of Physicians and Surgeons, Department of Neurosurgery/Neuro-oncology, National University of Singapore (NUS) - Department of Biological Sciences and Sun Yat-sen University (SYSU) - Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases