Fujita Health University - Department of Clinical Genetics, Kobe University - Division of Advanced Medical Science, Kobe University - Department of Chemical Science and Engineering, Kyoto University - Department of Clinical Application, Kobe University - Division of Advanced Medical Science, Fujita Health University - Department of Cellular Function Analysis, Asubio Pharma Co., Ltd., Asubio Pharma Co., Ltd., RIKEN Center for Developmental Biology - Laboratory for Cell Asymmetry, okyo Womens Medical University - Department of Pediatrics, Kyoto University - Department of Clinical Application, University of California, Los Angeles (UCLA) - Department of Neurobiology, University of California, Los Angeles (UCLA) - Department of Neurobiology, University of Tokyo - Department of Neurology, University of California, Irvine and Kobe University - Division of Advanced Medical Science