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Lie Nie

Shandong University

27 Shanda Nanlu

South Rd.

Jinan, SD 250100

China

Shandong Engineering Research Center for Transdermal Drug Delivery Systems

SCHOLARLY PAPERS

9

DOWNLOADS

343

TOTAL CITATIONS

2

Scholarly Papers (9)

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1.

Real-Time Monitoring, Release and Control Study of Continuous Manufacturing of Amlodipine Besylate Tablets Based on Near Infrared Spectroscopy

Number of pages: 31 Posted: 13 Mar 2024
Zhongyu Sun, Lifang Chen, Boran Lin, Haonan Zhou, Lie Nie, Liang Zhong, Wenping Yin, Hui Wang, Dongbo Xu, Yunshi Zhang, Bing Zhao, Qin Li, Kefan Zhang, Hui Zhang, Aoli Wu, Lian Li and Hengchang Zang
Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University and Shandong University
Downloads 72 (860,052)

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Amlodipine Besylate Tablets, Continuous Manufacturing, Near Infrared Spectroscopy, Real-time Monitoring, Real-time Release and Intelligent control

2.

Carbonized π-Conjugated Polymer Coated Porous Silica: Preparation and Evaluating Its Extraction Ability for Berberine Chloride

Downloads 64 (933,592)

Carbonized π-Conjugated Polymer Coated Porous Silica: Preparation and Evaluating Its Extraction Ability for Berberine Chloride

Number of pages: 30 Posted: 18 Apr 2022
Pian Jin, Fucheng Zhu, Mi Jiang, Makoto Takafuji, Hirotaka Ihara, Yuxia Luan, Lie Nie and Houmei Liu
Shandong University, Shandong First Medical University, Shandong University, Kumamoto University, Kumamoto University, Shandong University, Shandong University and Shandong University
Downloads 41 (1,210,354)

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berberine chloride, solid phase extraction, Adsorbent, carbonized polymer, urine

Carbonized Π-Conjugated Polymer Coated Porous Silica: Preparation and Evaluating its Extraction Ability for Berberine Chloride

Number of pages: 34 Posted: 16 Feb 2022
Pian Jin, Fucheng Zhu, Mi Jiang, Makoto Takafuji, Hirotaka Ihara, Yuxia Luan, Lie Nie and Houmei Liu
Shandong University, Shandong First Medical University, Shandong University, Kumamoto University, Kumamoto University, Shandong University, Shandong University and Shandong University
Downloads 23 (1,459,262)

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berberine chloride, solid phase extraction, adsorbent, carbonized polymer, urine

3.

Preliminary Discovery of Q-Marker of Xinkeshu Tablets Based on 'Fingerprint-Efficacy-Pharmacokinetics' Correlation

Number of pages: 27 Posted: 09 Jun 2021
Yongheng Wei, Lie Nie, Lele Gao, Liang Zhong, Xiangchun Yang, Jianan Yue, Yingzi Zeng, Lian Li and Hengchang Zang
Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong Wohua Pharmaceutical Technology Co., Ltd, Shandong University and Shandong University
Downloads 59 (970,490)

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4.

Integrating Deep Learning and Near-Infrared Spectroscopy for Quality Control of Traditional Chinese Medicine Extracts

Number of pages: 27 Posted: 04 Jun 2024
Cheng Peng, Mengyu Zhang, Mengdi Kong, Shudi Zhang, Chang Li, Tingting Feng, Weilu Tian, Lie Nie and Hengchang Zang
Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University and Shandong University
Downloads 53 (1,052,702)

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Traditional Chinese medicine, Near-infrared spectroscopy, Deep Learning, Modeling of CNN-GRU

5.

How Morphological Structure and Amino-Functional Group of Adsorbents Affect the Adsorption Properties for Phenolic Acids

Number of pages: 27 Posted: 11 Jan 2025
Tao Zhang, Chang Geng, Fucheng Zhu, Junyuan Quan, Wen Zhou, Na Li, Lie Nie and Houmei Liu
Shandong University, Shandong University, Shandong First Medical University, Shandong University, Shandong University, Qilu University of Technology, Shandong University and Shandong University
Downloads 31 (1,318,317)

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magnetic adsorbent, alkoxysilane, dendritic mesoporous silica, phenolic acids, adsorption

6.

Rapid Quantitative Analysis of Active Ingredients in Radix Gentianae Macrophyllae Extracts Based on Near-Infrared Spectroscopy and Deep Learning

Number of pages: 30 Posted: 13 May 2024
Cheng Peng, Mengyu Zhang, Mengdi Kong, Shudi Zhang, Chang Li, Tingting Feng, Weilu Tian, Lie Nie and Hengchang Zang
Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University and Shandong University
Downloads 21 (1,436,435)
Citation 2

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Radix Gentianae Macrophyllae, Near-infrared spectroscopy, deep learning, Modeling of CNN-GRU

7.

Application of Artificial Intelligence Combined with Near-Infrared Spectroscopy for Rapid Determination of Tack Adhesion in Transdermal Patches

Number of pages: 22 Posted: 20 May 2026
Hengchang Zang, Shuaihua Zhang, Cheng Peng, Shuang Zhang, Jia Li, Mengyu Zhang and Lie Nie
Shandong University, Shandong University, Shandong University, Shandong University, Shandong University, Shandong University and Shandong University
Downloads 15 (1,509,872)

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Near-infrared spectroscopy, transdermal patches, tack adhesion, convolutional neural network

8.

A Rapid Extraction Process Monitoring of Swertia Mussotii Franch. With Near Infrared Spectroscopy

Number of pages: 25 Posted: 09 Nov 2022
Mengqi Zhang, Bing Zhao, Lian Li, Lie Nie, Peipei Li, Jing Sun, Aoli Wu and Hengchang Zang
Shandong University, Shandong University, Shandong University - School of Pharmaceutical Sciences, Shandong University, affiliation not provided to SSRN, Chinese Academy of Sciences (CAS), Shandong University and Shandong University
Downloads 15 (1,500,778)

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Tibetan medicine, Swertia mussotii Franch., Extraction process, Near-infrared spectroscopy, Total quantum statistical moment

9.

Rapid Quantitative Analysis of Herbal Extraction Process using Near-infrared Spectroscopy: An Integrated Modeling Framework

Number of pages: 28 Posted: 13 May 2026
Mengyu Zhang, Wentian Wang, Shouyao Huang, Lie Nie, Chunguo Yang and Hengchang Zang
Shandong University, Shandong Yifang Pharmaceutical Co. Ltd., Shandong Yifang Pharmaceutical Co. Ltd., Shandong University, Shandong Yifang Pharmaceutical Co. Ltd. and Shandong University
Downloads 13 (1,548,648)

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herbal medicine, near-infrared spectroscopy, Generative adversarial network, Bayesian optimization, Model updating