Central South University - Center for Vascular Disease and Translational Medicine, Central South University - Center for Vascular Disease and Translational Medicine, Central South University - Center for Vascular Disease and Translational Medicine, Central South University - Center for Vascular Disease and Translational Medicine, Central South University - Center for Vascular Disease and Translational Medicine, Central South University - Department of Cardiology and Shanghai Jiao Tong University (SJTU)