University College London, University College London, Telethon Institute of Genetics and Medicine (TIGEM) - Armenise/Harvard Laboratory of Integrative Genomics, University College London, University College London, University College London, University College London, NIHR Great Ormond Street Biomedical Research Centre, University College London, Telethon Institute of Genetics and Medicine (TIGEM) - Armenise/Harvard Laboratory of Integrative Genomics, University College London, University College London - Great Ormond Street Institute of Child Health and University College London - Great Ormond Street Institute of Child Health