University of Cambridge - Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge - Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge - Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge - Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge - Wellcome Trust-MRC Institute of Metabolic Science, Nottingham University Hospitals NHS Trust - Department of Paediatric Diabetes and Endocrinology, University of Cambridge - Department of Paediatrics, Government of the United Kingdom - Department of Paediatric Diabetes, University of Colorado, Aurora - Barbara Davis Center for Childhood Diabetes, Stanford University - Division of Pediatric Endocrinology, University of Southampton - Department of Paediatric Endocrinology and Diabetes, Indiana University Purdue University Indianapolis (IUPUI) - Division of Pediatric Endocrinology and Diabetology, Nemours Children’s Health System - Division of Endocrinology, Diabetes & Metabolism, Government of the United Kingdom - NIHR Oxford Biomedical Research Centre, Alder Hey Children's NHS Foundation Trust, Yale University - Department of Pediatrics, Stanford University - Division of Pediatric Endocrinology, University of Southern California - Schaeffer Center for Health Policy and EconomicsUniversity of Southern California - Department of Pharmaceutical & Health Economics, Jaeb Center for Health Research (JCHR), Jaeb Center for Health Research (JCHR), Jaeb Center for Health Research Foundation, Inc.Jaeb Center for Health Research (JCHR), Jaeb Center for Health Research Foundation, Inc.Jaeb Center for Health Research (JCHR) and University of Cambridge - Wellcome Trust-MRC Institute of Metabolic Science