Johns Hopkins University - Neuroscience Critical Care Division, Macquarie University - Australian Institute of Health Innovation, Griffith University - School of Medicine, University of Genova - Department of Surgical Science and Integrated Diagnostics (DISC), University of Queensland - Prince Charles Hospital, University of Queensland, University of Queensland - Critical Care Research Group, University of Queensland - Critical Care Research Group, Università degli Studi di Genova, University of Utah Health, University of Liverpool, University of Liverpool - Institute of Infection and Global Health, University of Cape Town (UCT) - Groote Schuur Hospital and affiliation not provided to SSRN