Washington University in St. Louis - Department of Developmental Biology, Washington University in St. Louis - Department of Neurology, University College London - UK Dementia Research Institute, Northwestern University - Department of Molecular Biosciences, Washington University in St. Louis - Department of Neurology, Washington University in St. Louis - Department of Neurology, Northwestern University - Department of Molecular Biosciences, affiliation not provided to SSRN, Washington University in St. Louis - Knight Alzheimer Disease Research Center, University College London - UK Dementia Research Institute, Northwestern University - Department of Molecular Biosciences, Washington University in St. Louis - Department of Neurology, University College London - UK Dementia Research Institute and Washington University School of Medicine - Department of Developmental Biology