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Siqiao Sun

Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital

Beijing, 100039

China

  • Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital

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Nortriptyline Induces Sterile Inflammation by Directly Targeting NLRP3 Inflammasome Activation

Number of pages: 32 Posted: 13 Aug 2021
Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Dai Wenzhang, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai and Xiaohe Xiao
Government of the People's Republic of China - Senior Department of Hepatology, Government of the People's Republic of China - Senior Department of Hepatology, Government of the People's Republic of China - China Military Institute of Chinese Materia, Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital, Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital, Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital, Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital, Government of the People's Republic of China - Fifth Medical Center of Chinese PLA General Hospital, Government of the People's Republic of China - Military Patient Management Department, Government of the People's Republic of China - China Military Institute of Chinese Materia, Government of the People's Republic of China - China Military Institute of Chinese Materia, Government of the People's Republic of China - Senior Department of Hepatology and Government of the People's Republic of China - Senior Department of Hepatology
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Abstract:

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Hepatotoxicity; Tricyclic antidepressant; NLRP3 inflammasome; Gasdermin D; Mitochondrial reactive oxygen species