affiliation not provided to SSRN, Department of Pediatric and Adolescent Oncology, Institut Gustave Roussy, affiliation not provided to SSRN, Utrecht University - University Medical Center (Utrecht), Princess Maxima Center for Pediatric Oncology, Centre Alexis Vautrin, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Princess Máxima Center for Pediatric Oncology and University of Padua - Department of Women’s and Children’s Health