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Jana Held

University of Tübingen

SCHOLARLY PAPERS

2

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124

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Scholarly Papers (2)

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1.

Efficacy and Safety of Ivermectin for the Treatment of Plasmodium Falciparum Infections in Asymptomatic Gabonese Adults – A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Number of pages: 23 Posted: 15 Mar 2023
Dorothea Ekoka Mbassi, Ghyslain Mombo-Ngoma, Jana Held, Dearie Glory Okwu, Wilfrid Ndzebe-Ndoumba, Laura C. Kalkman, Franck Aurelien Ekoka Mbassi, Laís Pessanha de Carvalho, Juliana Inoue, Malik A. Akinosho, Lia Betty Dimessa Mbadinga Weyat, Emmanuel Koffi Yovo, Benjamin Mordmüller, Peter G. Kremsner, Ayôla Akim Adegnika, Michael Ramharter and Rella Zoleko-Manego
Lambaréné Medical Research Center (CERMEL), Lambaréné, Lambaréné Medical Research Center (CERMEL), Lambaréné, University of Tübingen, Lambaréné Medical Research Center (CERMEL), Lambaréné, Lambaréné Medical Research Center (CERMEL), Lambaréné, Lambaréné Medical Research Center (CERMEL), Lambaréné, Lambaréné Medical Research Center (CERMEL), Lambaréné, University of Tübingen - Institute of Tropical Medicine, University of Tübingen - Institute of Tropical Medicine, Lambaréné Medical Research Center (CERMEL), Lambaréné, Lambaréné Medical Research Center (CERMEL), Lambaréné, Lambaréné Medical Research Center (CERMEL), Lambaréné, University of Tübingen - Institute of Tropical Medicine, Lambaréné Medical Research Center (CERMEL), Lambaréné, Lambaréné Medical Research Center (CERMEL), Lambaréné, University of Hamburg - University Medical Center Hamburg-Eppendorf and Lambaréné Medical Research Center (CERMEL), Lambaréné
Downloads 73 (852,604)

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Ivermectin, Plasmodium falciparum, Blood stages, In vitro activity, In vivo efficacy, Dose-escalation, Randomized, Double-blind, safety, Adverse events, Parasite reduction, Transmission, Antiparasitic effect, Lambaréné, Gabon, Parasite load reduction, Tolerability, Mosquitocidal effect

2.

Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Sub-Pocket of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (DXR)

Number of pages: 35 Posted: 14 Dec 2023
Mona A. Abdullaziz, Sana Takada, Boris Illarionov, Lais Pessanha de Carvalho, Yasumitsu Sakamoto, Stefan Höfmann, Talea Knak, Anna-Lene Kiffe-Delf, Flaminia Mazzone, Klaus Pfeffer, Rainer Kalscheuer, Adelbert Bacher, Jana Held, Markus Fischer, Nobutada Tanak and Thomas Kurz
Heinrich Heine University Dusseldorf, Kitasato University, University of Hamburg, Eberhard-Karls University Tübingen, Iwate Medical University, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf, University of Hamburg, University of Tübingen, University of Hamburg, Kitasato University and Heinrich Heine University Dusseldorf
Downloads 51 (1,052,702)

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Fosmidomycin, N-substituted hydroxamic acids, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR, IspC), non-mevalonate biosynthesis pathway, antiplasmodial activity, co crystal structures.