University of Cambridge - Cambridge Institute for Therapeutic Immunology and Infectious Disease, University of Cambridge - Cambridge Institute for Therapeutic Immunology and Infectious Disease, Cambridge University Teaching Hospital, Addenbrooke's - Department of Infectious Diseases, affiliation not provided to SSRN, University of Cambridge - Cambridge Institute for Therapeutic Immunology and Infectious Disease, National Institutes for Health Research (NIHR) Cambridge Biomedical Research Centre, University of Cambridge - Department of Medicine, University of Cambridge - Cambridge Institute for Therapeutic Immunology and Infectious Disease, Cambridge University NHS Hospitals Foundation Trust - Department of Infectious Diseases, University of Cambridge - Cambridge Institute for Therapeutic Immunology and Infectious Disease, University of Cambridge - Cambridge Institute for Therapeutic Immunology and Infectious Disease, University of Cambridge - Cambridge Institute for Therapeutic Immunology and Infectious Disease and University of Cambridge - Cambridge Institute for Therapeutic Immunology and Infectious Disease