Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Quantitative Engineering Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Quantitative Engineering Biology, Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Quantitative Engineering Biology, Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Quantitative Engineering Biology, Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Quantitative Engineering Biology, Northwestern Polytechnical University - Department of Applied Mathematics, Sun Yat-sen University (SYSU) - Department of Colorectal Surgery, Xbiome, Xbiome, Chinese Academy of Sciences (CAS) - Brain Cognition and Brain Disease Institute (BCBDI), Chinese Academy of Sciences (CAS) - Brain Cognition and Brain Disease Institute (BCBDI), Brigham and Women’s Hospital - Channing Division of Network Medicine and Chinese Academy of Sciences (CAS) - CAS Key Laboratory of Quantitative Engineering Biology