Spedali Civili University Hospital, University of Brescia - Department of Molecular and Translational Medicine, Università degli Studi di Genova, Université Libre de Bruxelles (ULB) - Department of Intensive Care, Fondazione Policlinico Universitario A. Gemelli IRCCS, University of Valencia - Department of Anesthesiology and Intensive Care, ASST-Spedali Civili of Brescia - Department of Anesthesia, ASST - Monza - San Gerardo Hospital, ASST - Monza - San Gerardo Hospital, Cleveland Clinic - Cerebrovascular center of neurological Institute, Grande Ospedale Metropolitano Niguarda - Department of Neurointensive Care, Azienda Ospedaliera Universitaria Pisana - Department of Anesthesiology and Critical Care, Papa Giovanni XXIII Hospital, Legnano Hospital, Columbia University - Division of Hospital and Critical Care Neurology, affiliation not provided to SSRN, Grenoble Alpes University Hospital, affiliation not provided to SSRN, Grande Ospedale Metropolitano Niguarda, affiliation not provided to SSRN, affiliation not provided to SSRN, OSPEDALE DI CIRCOLO DI VARESE - ASST-SETTELAGHI, University of Toronto, affiliation not provided to SSRN and ASST-Spedali Civili of Brescia - Intensive Care and Emergency