Kumamoto University - Department of Chromosome Biology, Kumamoto University - Department of Chromosome Biology, affiliation not provided to SSRN, Kumamoto University - Department of Chromosome Biology, Kumamoto University - Liaison Laboratory Research Promotion Center, Kumamoto University - Liaison Laboratory Research Promotion Center, Kumamoto University - Institute of Resource Development and Analysis and Center for Metabolic Regulation of Healthy Aging, Kumamoto University - Institute of Resource Development and Analysis and Center for Metabolic Regulation of Healthy Aging and Kumamoto University - Department of Chromosome Biology