Toho University Sakura Medical Center - Department of Internal Medicine, Tokyo Medical and Dental University - Department of Gastroenterology and Hepatology, Ohmori Toshihide gastro-intestinal Clinic - Gastroenterology, Matsushima Clinic Yokohama Japan - Department of gastrointestinal division, Ishida Clinic of IBD and Gastroenterology - IBD and Gastroenterology, National Hospital Organization Hirosaki National Hospital - Department of Gastroenterology and Hematology, Kanke Gastrointestinal Clinic - Gastrointestinal division, Kitasato University - Research and Development Center for New Medical Frontiers, Fukuoka University Chikushi Hospital - Department of Gastroenterology, Hyogo College of Medicine - Center for Inflammatory Bowel Disease, Division of Internal Medicine, National Center of Neurology and Psychiatry, National Center of Neurology and Psychiatry (NCNP) Hospital - Department of Neurology, Komagome Hospital - Department of Neurology, EA Pharma Co., Ltd. - Clinical Development Department, EA Pharma Co., Ltd. - Clinical Development Department, Kitasato University - Center for Advanced IBD Research and Treatment and Toho University Sakura Medical Center, Division of Gastroenterology and Hepatology, Department of Internal Medicine