National Sun Yat-sen University - Institute of Biomedical Sciences, China Medical University - Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital - Department of Obstetrics and Gynecology, Taichung Hospital, Ministry of Health and Welfare - Department of Pathology, National Sun Yat-sen University - Institute of Biomedical Sciences, National Sun Yat-sen University - Institute of Biomedical Sciences, China Medical University - School of Chinese Medicine, China Medical University - School of Chinese Medicine, Kaohsiung Veterans General Hospital - Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital - Department of Obstetrics and Gynecology, China Medical University - Human Genetic Center, National Sun Yat-sen University - Institute of Biomedical Sciences and China Medical University - School of Chinese Medicine