Government of the United Kingdom - Royal Brompton Hospital, London School of Hygiene & Tropical Medicine, Cystic Fibrosis Foundation, Cystic Fibrosis Foundation, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Assistance Publique-Hopitaux de Paris (AP-HP) - Assistance Publique-Hôpitaux de Paris, University of Auckland - Paediatric Department, affiliation not provided to SSRN, affiliation not provided to SSRN, Hôpital Trousseau - Centre de Ressources et de Compétence pour la Mucoviscidose, Sciensano, University of Washington, affiliation not provided to SSRN, University of Alabama at Birmingham, Yerevan State Medical University, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, The University of Sydney - Westmead Hospital, Pediatric Pulmonology and Cystic Fibrosis Unit, Karolinska Institutet, Justus Liebig University Giessen - Department of Paediatrics, affiliation not provided to SSRN, Cystic Fibrosis Foundation, Hospital Universitario Cruces, Cystic Fibrosis Foundation, Monash University - Institute for Safety - Compensation and Recovery Research, Istituto Superiore di Sanità, Universidade Metodista de São Paulo, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Cystic Fibrosis Foundation and affiliation not provided to SSRN