affiliation not provided to SSRN, Harvard University - Massachusetts General Hospital, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Toronto - University Health Network, affiliation not provided to SSRN, Massachusetts General Hospital, Harvard Medical School, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Erasmus University Medical Center - Department of Urology & Depratment of Immunology, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Toronto - University Health Network, University of Toronto - University Health Network, Viral Hepatitis Care Network (VIRCAN), Harvard University - Liver Center, Erasmus University Rotterdam (EUR) - Department of Gastroenterology & Hepatology, Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, University of Toronto, Janssen Pharmaceutical K.K. - Infectious Diseases Translational Biomarkers, affiliation not provided to SSRN, Massachusetts General Hospital and Harvard Medical School - Center for Cancer Immunology, Harvard University - Liver Center, affiliation not provided to SSRN, Massachusetts Institute of Technology (MIT) - Institute for Medical Engineering and Science and Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, University of Toronto