Imperial College London - National Heart and Lung Institute, University of California, Davis - Division of Pulmonary, Critical Care and Sleep Medicine, Imperial College London - National Heart and Lung Institute, University of Leicester - Department of Health Sciences, University of Leicester - Department of Health Sciences, GlaxoSmithKline - Discovery Medicine, University of Nottingham - Nottingham Respiratory Research Unit, University of Nottingham - Nottingham Respiratory Research Unit, University of Nottingham, Nordic Bioscience, Nordic Bioscience, University of Nottingham - Computational Optimisation and Learning Lab, GlaxoSmithKline - Discovery Medicine, Imperial College London - National Heart and Lung Institute, Imperial College London - National Heart and Lung Institute, University of Leicester - Department of Health Sciences, University of Virginia - Department of Pulmonary and Critical Care Medicine, Imperial College London - National Heart and Lung Institute, Imperial College London - National Heart and Lung Institute and Imperial College London - National Heart and Lung Institute