Shanghai Institute for Biomedical and Pharmaceutical Technologies, Tongji University - Shanghai First Maternity and Infant Hospital, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University - NHC Key Lab of Reproduction Regulation, affiliation not provided to SSRN, Harvard University - Harvard Medical School, Hubei Provincial Center for Disease Control and Prevention, Shanghai Institute for Biomedical and Pharmaceutical Technologies and Shanghai Institute for Biomedical and Pharmaceutical Technologies