affiliation not provided to SSRN, affiliation not provided to SSRN, University College London - University College London Hospitals NHS Foundation Trust, Queen Alexandra Hospital, Queen Alexandra Hospital, Queen Alexandra Hospital, Queen Alexandra Hospital, Nottingham University Hospitals NHS Trust, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, King’s College Hospital NHS Foundation Trust, Government of the United Kingdom - Queen Elizabeth University Hospital, University College London - University College London Hospitals NHS Foundation Trust, affiliation not provided to SSRN, University College London - University College London Hospitals NHS Foundation Trust, University College London - University College London Hospitals NHS Foundation Trust, University College London - University College London Hospitals NHS Foundation Trust and University College Hospital