affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of California, Irvine, University of California, Irvine, University of California, Irvine, University of California, Irvine, University of California, Irvine, University of California, Irvine and Huntington Medical Research Institutes - Cardiovascular Research Institute