University of Lisbon - Institute of Molecular Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Yale University - Cardiovascular Research Center, University of Lisbon - Institute of Molecular Medicine, affiliation not provided to SSRN, University of Lisbon - Institute of Molecular Medicine, University of Edinburgh - Centre for Medical Informatics, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Lisbon - Institute of Molecular Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, Yale University - Cardiovascular Research Center and University of Edinburgh - Centre for Medical Informatics