affiliation not provided to SSRN, University of Groningen - University Medical Center Groningen (UMCG), affiliation not provided to SSRN, University of Groningen - University Medical Center Groningen (UMCG), affiliation not provided to SSRN, University of Groningen - European Research Institute for the Biology of Ageing (ERIBA), University of Groningen - European Research Institute for the Biology of Ageing (ERIBA), University of Pittsburgh - Department of Medicine and Pulmonary and Critical Care Medicine, University of Groningen, affiliation not provided to SSRN and University of Groningen - Groningen Research Institute for Asthma and COPD (GRIAC)