Newcastle University - Biosciences Institute, Newcastle University, University of Cambridge - MRC Laboratory of Molecular Biology, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Glasgow, affiliation not provided to SSRN, Newcastle University - Biosciences Institute, University of Birmingham, University of Birmingham, Massachusetts Institute of Technology (MIT) - Whitehead Institute for Biomedical Research, University of Liverpool, affiliation not provided to SSRN, University of Glasgow, affiliation not provided to SSRN, The Procter and Gamble Company, affiliation not provided to SSRN, affiliation not provided to SSRN, The Procter and Gamble Company, Newcastle University - Biosciences Institute, Monash University, Massachusetts Institute of Technology (MIT) - Whitehead Institute for Biomedical Research, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Liverpool, University of Glasgow, University of Glasgow, University of Birmingham - Institute of Cancer and Genomic Sciences and Newcastle University - Biosciences Institute