affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Chinese Academy of Medical Sciences - Department of Medical Oncology, Tianjin Medical University - National Clinical Research Center for Cancer, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), affiliation not provided to SSRN, Tianjin Medical University - National Clinical Research Center for Cancer, Tianjin Medical University - National Clinical Research Center for Cancer, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Geneplus Beijing Institute, Geneplus Beijing Institute, Geneplus-Beijing Institute, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN and affiliation not provided to SSRN