Jiangnan University, Jiangnan University, Sun Yat-Sen University (SYSU), Zhongshan School of Medicine, Sun Yat-Sen Memorial Hospital, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen University (SYSU), Zhongshan School of Medicine, Sun Yat-Sen Memorial Hospital, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Jiangnan University, Sun Yat-Sen University (SYSU) - Department of Pancreato-Biliary Surgery, Max Planck Society for the Advancement of the Sciences - Department of Biomolecular Systems and Jiangnan University - Key Laboratory of Carbohydrate Chemistry and Biotechnology