Zhengzhou University - Henan Provincial People's Hospital, University of Pennsylvania - Department of Biostatistics, Epidemiology, and Informatics, Zhengzhou University - Henan Provincial People's Hospital, Washington University in St. Louis - Division of Public Health Sciences, Zhengzhou University - Henan Provincial People's Hospital, Sun Yat-sen University (SYSU) - Department of Neurology, Zhengzhou University - Henan Provincial People's Hospital, Zhengzhou University - Henan Provincial People's Hospital, Zhengzhou University - Henan Provincial People's Hospital, Zhengzhou University - Henan Provincial People's Hospital, Sun Yat-sen University (SYSU) - Department of Neurology, University of Pennsylvania - Perelman School of Medicine, Sun Yat-sen University (SYSU) - Department of Neurology and Zhengzhou University - Henan Provincial People's Hospital