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Guang Sheng Ling

The University of Hong Kong - School of Biomedical Sciences

Pokfulam Road

Hong Kong, +852-2559-0468 HK

China

  • The University of Hong Kong - School of Biomedical Sciences

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Chronic Type I Interferons Signaling Promotes Lipid Peroxidation-Driven Terminal CD8 +T Cell Exhaustion and Curtails Anti-PD-1 Treatment Efficacy

Number of pages: 41 Posted: 11 Mar 2022
Weixin Chen, Jia Ming Nickolas Teo, Siu Wah Yau, Yee-Man Melody Wong, Chun-Nam Lok, Chi-Ming Che, Asif Javed, Yuanhua Huang, Stephanie Ma and Guang Sheng Ling
The University of Hong Kong - School of Biomedical Sciences, The University of Hong Kong - School of Biomedical Sciences, The University of Hong Kong - School of Biomedical Sciences, Hong Kong Science and Technology Parks - Laboratory for Synthetic Chemistry and Chemical Biology, The University of Hong Kong - State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The University of Hong Kong - State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The University of Hong Kong - School of Biomedical Sciences, The University of Hong Kong - School of Biomedical Sciences, The University of Hong Kong - School of Biomedical Sciences and The University of Hong Kong - School of Biomedical Sciences
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Chronic IFN-Is signaling, CD8+T cell exhaustion, dysregulated lipid metabolism, anti-PD-1 therapy resistance