University of Birmingham, University of Birmingham, Massachusetts Institute of Technology (MIT) - Whitehead Institute for Biomedical Research, University of Birmingham, University of Birmingham - Institute of Metabolism and Systems Research, University of Birmingham, University of Birmingham, Newcastle University, Newcastle University - Biosciences Institute, University of Cambridge - MRC Laboratory of Molecular Biology, University of Birmingham, affiliation not provided to SSRN, University of Glasgow, University of Birmingham, University of Birmingham, University of Birmingham, Massachusetts Institute of Technology (MIT) - Whitehead Institute for Biomedical Research, University of Birmingham, affiliation not provided to SSRN, University of Birmingham, affiliation not provided to SSRN, affiliation not provided to SSRN, Oregon State University, affiliation not provided to SSRN, University of Birmingham - Institute of Metabolism and Systems Research, University of British Columbia (UBC) - Department of Biochemistry and Molecular Biology, Massachusetts Institute of Technology (MIT) - Institute for Medical Engineering and Science, University of Birmingham, University of Birmingham, University of Glasgow, University of Birmingham - Institute of Metabolism and Systems Research, affiliation not provided to SSRN, Massachusetts Institute of Technology (MIT) - Whitehead Institute for Biomedical Research, Newcastle University and University of Birmingham - Institute of Cancer and Genomic Sciences