affiliation not provided to SSRN, Vall d'Hebron Institute of Oncology (VHIO), affiliation not provided to SSRN, affiliation not provided to SSRN, University of Pisa - Department of Translational Research and of New Surgical and Medical Technologies, affiliation not provided to SSRN, Fondazione IRCCS Istituto Nazionale dei Tumori, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Institute of Oncology (VHIO), affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Ospedale Santa Chiara - Azienda Ospedaliero Universitaria Pisana, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Medical Oncology 1, Fondazione Policlinico Universitario A. Gemelli IRCCS - Oncologia Medica, University Hospital of Pisa - Unit of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) - Department of Medical Oncology, Careggi University Hospital of Florence - Clinical Oncology Unit, Ospedale Santa Chiara - Azienda Ospedaliero Universitaria Pisana, AUSL Romagna - Oncology Unit, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - IRCCS Veneto Institute of Oncology (IOV-IRCCS), Fondazione IRCCS Istituto Nazionale dei Tumori - Department of Medical Oncology, University Hospital of Pisa - Unit of Medical Oncology, Vall d’Hebron Institute of Oncology (VHIO)Hospital Vall d’Hebron and Vall d’Hebron Institute of Oncology (VHIO)