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Patrick Augustijns

KU Leuven

SCHOLARLY PAPERS

5

DOWNLOADS

313

TOTAL CITATIONS

0

Scholarly Papers (5)

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1.

Challenges in Predicting Colonic Luminal and Tissue Concentrations of Mesalamine and Acetyl Mesalamine Using Physiologically Based Biopharmaceutics Modeling

Number of pages: 25 Posted: 19 Feb 2025
Harshad Jadhav, Arno Van Camp, Christer Tannergren, Glenn Lemmens, Joachim Brouwers, Tim Vanuytsel, Sebastian Steigert and Patrick Augustijns
AstraZeneca Pharmaceuticals - Sweden, KU Leuven, AstraZeneca Pharmaceuticals - Sweden, KU Leuven, KU Leuven, UZ Leuven, KU Leuven and KU Leuven
Downloads 114 (630,858)

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absorption, Biopharmaceutics Modeling, Colonic luminal concentration, Mesalamine, NAT1, Tissue concentration, PBBM

2.

Physiologically Based Biopharmaceutics Modeling of Regional and Colon Absorption in Humans

Number of pages: 52 Posted: 03 Mar 2023
Christer Tannergren, Harshad Jadhav, Emma Eckernäs, Jonas Fagerberg, Patrick Augustijns and Erik Sjögren
AstraZeneca Pharmaceuticals - Sweden, AstraZeneca Pharmaceuticals - Sweden, University of Gothenburg - Sahlgrenska Academy, Disruptive Pharma AB, KU Leuven and Uppsala University - Department of Pharmaceutical Biosciences
Downloads 75 (837,727)

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physiologically based biopharmaceutics modelling, PBPK, PBBM, Colon absorption, regional absorption, relative bioavailability, permeability, solubility, extended release, colon targeting

3.

Structured Solubility Behaviour in Bioequivalent Fasted Simulated Intestinal Fluids

Number of pages: 37 Posted: 16 Mar 2022
Qamar Abuhassan, Ibrahim Khadra, Kate Pyper, Patrick Augustijns, Joachim Brouwers and Gavin Halbert
University of Strathclyde - Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde - Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde - Department of Mathematics & Statistics, KU Leuven, KU Leuven and University of Strathclyde - Strathclyde Institute of Pharmacy and Biomedical Science
Downloads 47 (1,097,529)

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fasted simulated intestinal fluid, equilibrium solubility, acidic drugs, basic drugs, neutral drugs

4.

Β-D-N 4-Hydroxycytidine (NHC, EIDD-1931) Inhibits Chikungunya Virus Replication in Mosquito Cells and Ex Vivo Aedes Aegypti Guts, But Not When Ingested During Blood-Feeding

Number of pages: 34 Posted: 23 Jan 2024
Ana Lucia Rosales Rosas, Alina Soto, Lanjiao Wang, Raf Mols, Albin Fontaine, Aboubakar Sanon, Patrick Augustijns and Leen Delang
KU Leuven, KU Leuven, KU Leuven, KU Leuven, Aix-Marseille University, KU Leuven, KU Leuven and Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven
Downloads 39 (1,196,171)

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CHIKV, Aedes aegypti, Mosquito, antiviral drug, NHC, EIDD-1931

5.

The Influence of Individual Gastrointestinal Physiology Parameters on Prediction of Regional Drug Absorption

Number of pages: 19 Posted: 13 May 2025
Harshad Jadhav, Patrick Augustijns and Christer Tannergren
AstraZeneca Pharmaceuticals - Sweden, KU Leuven and AstraZeneca Pharmaceuticals - Sweden
Downloads 38 (1,209,354)

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PBBM, IntelliCap, GastroPlus, GI-Sim, Colon absorption, Biopharmaceutics modeling, Regional absorption