Goethe University Frankfurt - Diagnostic Center of Acute Leukemia (DCAL), Goethe University Frankfurt - Diagnostic Center of Acute Leukemia (DCAL), Goethe University Frankfurt - Diagnostic Center of Acute Leukemia (DCAL), Goethe University Frankfurt - Diagnostic Center of Acute Leukemia (DCAL), Schleswig-Holstein University - Department of Pediatrics, Schleswig-Holstein University - Department of Pediatrics, Charité - Universitätsmedizin Berlin - Department of Paediatric Oncology and Haematology, AP-HP Hôpital R. Debré - Département de Génétique, AP-HP Hôpital R. Debré - Département de Génétique, University of Milano Bicocca - Centro Ricerca M. Tettamanti, Paediatrics, University of Milan - Bicocca - Centro Ricerca Tettamanti, Pediatrics, University of Milano-Bicocca - Paediatrics, University of Milano-Bicocca - Centre of Biostatistics for Clinical Epidemiology, Goethe University Frankfurt - Institute for Transfusion Medicine and Immunohematology, Goethe University Frankfurt - Institute for Transfusion Medicine and Immunohematology, Goethe University Frankfurt - Diagnostic Center of Acute Leukemia (DCAL) and Goethe University Frankfurt - Institute of Pharmaceutical Chemistry