Manchester Academic Health Sciences Centre - The Christie NHS Foundation Trust, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, The University of Sydney - Melanoma Institute Australia, affiliation not provided to SSRN, The University of Manchester, The Christie NHS Foundation Trust, Blacktown Hospital, The University of Sydney - Melanoma Institute Australia, Hospital of Barcelona, Vanderbilt University - Vanderbilt-Ingram Cancer Center, The University of Sydney - Melanoma Institute Australia, Royal Marsden NHS Foundation Trust - Renal and Skin Units, NHS Foundation Trust - Royal Marsden Hospital, Netherlands Cancer Institute and The University of Manchester