affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Charité–Universitätsmedizin Berlin, University of Southern California, University of Southern California - Norris Comprehensive Cancer Center, University of Southern California - Norris Comprehensive Cancer Center, University of Southern California - Norris Comprehensive Cancer Center, University of Southern California - Norris Comprehensive Cancer Center, University of Southern California - Norris Comprehensive Cancer Center, University of Southern California - Norris Comprehensive Cancer Center, affiliation not provided to SSRN, University Hospital of Pisa - Unit of Medical Oncology, affiliation not provided to SSRN, LMU Munich - Department of Hematology/Oncology, University of Pisa - Department of Oncology, Peking University - Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), University of Southern California and University of Southern California - Norris Comprehensive Cancer Center