Kristen L. Lauing

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Identification and Characterization of a Novel Brain-Penetrant Indoleamine 2,3 Dioxygenase 1 Protein Degrader for Glioblastoma

Number of pages: 77 Posted: 11 Apr 2022
Lakshmi Bollu, Prashant V. Bommi, Paige J. Monsen, Lijie Zhai, Kristen L. Lauing, April Bell, Miri Kim, Erik Ladomersky, Leonidas C. Platanias, Daniela E. Matei, Marcelo G. Bonini, Hidayatullah G. Munshi, Rintaro Hashizume, Jennifer D. Wu, Bin Zhang, C. David James, Peiwen Chen, Masha Kocherginsky, Craig Horbinski, Michael D. Cameron, Arabela A. Grigorescu, Bakhtiar Yamini, Rimas V. Lukas, Gary E. Schiltz and Derek Alan Wainwright
affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Loyola University of Chicago - Loyola University Medical Center, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, The Scripps Research Institute - Department of Chemistry, Northwestern University, University of Chicago, affiliation not provided to SSRN, affiliation not provided to SSRN and Northwestern University Feinberg School of Medicine - Department of Neurological Surgery
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Abstract:

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IDO, PROTAC, glioma, complement, NF-κB, aging, checkpoint, metabolism, tryptophan, kynurenine, brain tumor, colon cancer, breast, prostate, pancreatic