Hokkaido University - Department of Molecular Psychoimmunology, Hokkaido University, affiliation not provided to SSRN, Hokkaido University - Department of Molecular Psychoimmunology, Hokkaido University - Department of Microbiology and Immunology, Hokkaido University, Hokkaido University, affiliation not provided to SSRN, Hokkaido University - Department of Hematology Medicine, Hokkaido University - Department of Biostatistics, Hokkaido University - Department of Microbiology and Immunology, Hokkaido University - Department of Molecular Psychoimmunology and Hokkaido University - International Medical Department