affiliation not provided to SSRN, Kilimanjaro Christian Medical University College - Kilimanjaro Clinical Research Institute, Haydom Lutheran Hospital, affiliation not provided to SSRN, Haydom Lutheran Hospital, University of Virginia, affiliation not provided to SSRN, University of Florida - College of Pharmacy, Haydom Lutheran Hospital, Kibong’oto Infectious Diseases Hospital, University of Virginia, University of Virginia - School of Medicine, University of Venda, University of Venda, University of Virginia and University of Virginia