University of Tokyo - Center for Disease Biology and Integrative Medicine, University of Tokyo - Laboratory of Clinical Biotechnology, Tokyo Dental College - Department of Biochemistry, University of Tokyo - Sensory and Motor System Medicine, University of Tokyo, Graduate School of Frontier Sciences, Department of Computational Biology and Medical Sciences, University of Tokyo, Graduate School of Frontier Sciences, Department of Computational Biology and Medical Sciences, University of Connecticut - Department of Reconstructive Sciences, University of Connecticut - Department of Reconstructive Sciences, University of Tokyo - Orthopaedic Surgery, University of Tokyo - Department of Bioengineering, University of Tokyo - Laboratory of Clinical Biotechnology, University of Tokyo - Center for Disease Biology and Integrative Medicine and University of Tokyo - Center for Disease Biology and Integrative Medicine