affiliation not provided to SSRN, affiliation not provided to SSRN, Southeast University - Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research and School of Chemistry and Chemical Engineering, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Capital Medical University, Sun Yat-sen University (SYSU) - Eighth Affiliated Hospital and Southeast University - Key Laboratory for Developmental Genes and Human Disease