University of Bristol - Department of Diabetes and Metabolism, Queen Mary University of London - Blizard Institute, University of Bristol - Department of Diabetes and Metabolism, University of Bristol - Department of Diabetes and Metabolism, University of Bristol - Department of Diabetes and Metabolism, Queen Mary University of London - Blizard Institute, Independent, Independent, SomaLogic, University of Oxford - Kennedy Institute of Rheumatology, Imperial College London - Faculty of Medicine, University of Exeter - Institute of Biomedical and Clinical Science, University of Bristol - Department of Diabetes and Metabolism, University of Bristol - Department of Diabetes and Metabolism, Queen Mary University of London - Blizard Institute and University of Bristol - Department of Diabetes and Metabolism