Saiseikai Utsunomiya Hospital, Juntendo University - Graduate School of Medicine, Nara Medical University - Department of Cardiovascular Medicine, Juntendo University - Graduate School of Medicine, Juntendo University - Graduate School of Medicine, National Cerebral and Cardiovascular Centre, National Cerebral and Cardiovascular Centre, Yokohama City University - Medical Center, Fukushima Medical University, University of Tsukuba, Tsukuba Advanced Research Alliance (TARA), Faculty of Medicine, St. Marianna University - School of Medicine, Nagoya University - Graduate School of Medicine, Nara Medical University - Department of Cardiovascular Medicine, Nara Medical University - Department of Cardiovascular Medicine, Nara Medical University - Department of Cardiovascular Medicine, Nara Medical University - Department of Cardiovascular Medicine, Nara Medical University - Department of Cardiovascular Medicine and Juntendo University - Department of Cardiovascular Biology and Medicine