Cornell University - Department of Neurology, Cornell University - Department of Neurology, Cornell University - Department of Neurology, Northwestern University - Department of Neurology, Columbia University - Vagelos College of Physicians and Surgeons (P&S), Columbia University - Department of Biostatistics, Columbia University - Department of Biostatistics, Swedish Neuroscience Institute, Columbia University - Irving Medical CenterColumbia University - Columbia Multiple Sclerosis Center, Columbia University - Irving Medical CenterColumbia University - Center for Translational and Systems Neuroimmunology, Columbia University - Irving Medical Center, Columbia University - Columbia Multiple Sclerosis Center, Cornell University - Weill Cornell Medicine, Cornell University - Department of Pediatrics, Cornell University - Department of Pediatrics, Cornell University - Department of Pediatrics, Mount Sinai Health System - Department of Neurology, Mount Sinai Health System - Department of Neurology, Cornell University - Department of Pediatrics, Mount Sinai Health System - Department of Neurology, Mount Sinai Health System - Department of Neurology, Government of the United States of America - National Institute of Neurological Disorders and Stroke (NINDS), Columbia University - Department of Epidemiology, Cornell University - Department of Pediatrics, Mount Sinai Health System - Department of Neurology and Department of Neurology - Columbia University Irving Medical Center