Chinese Ministry of Education - The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Harbin Medical University, Harbin Medical University, Harbin Medical University, Second Affiliated Hospital, Department of Cardiology, Huazhong University of Science and Technology - Union Shenzhen Hospital, University of Texas at Houston - MD Anderson Cancer Center, Harbin Medical University, Second Affiliated Hospital, Department of Cardiology, Queen’s University, Harbin Medical University - Department of Pathophysiology and Harbin Medical University, Second Affiliated Hospital, Department of Cardiology