Zhejiang University - Department of Endocrinology and Metabolism, Zhejiang University - Department of Endocrinology and Metabolism, Zhejiang University - Department of Endocrinology and Metabolism, Zhejiang Hospital, Ningbo University, Rensselaer Polytechnic Institute (RPI) - Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute (RPI) - Center for Biotechnology and Interdisciplinary Studies, Zhejiang University of Technology and Zhejiang University - Department of Endocrinology and Metabolism